We provide unique scaffolds for in vitro cell and pharmacology research and development, with particular relevance to stem cells and cancer cells.
New anisotropic GAIN scaffolds (graphene-augmented inorganic nanofibers) combine benefits of the 3D and 2D technology features for co-cultures, ALICE assays, bipolar assays with selective media separation, providing from 15 to 550 billions of highly aligned nanofibers per one square centimeter area. Due to these features, scaffolds exhibit a "2.5D" behavior in signalling which is somewhat analogous to neural communication.
The combination of tailored porosity, associated permittivity, ultra-high anisotropy, augmented shell stiffness and transport properties opens new perspectives and scenarios to GAIN outcomes in in vitro experiments especially for:
- tissue engineering and pharma studies for dermal, neural, cochlear, nephrology, hepatic and other fields for ATMP experiments, e.g. for Alzheimer, Parkinson and similar drugs R&D.
- toxicology at true 1R (total replacement) methods beyond the 3R -directive (2010/63/EC) framework
- design and improvement novel concepts including those for omics, cancer cells immobilization and fine featuring.
NEW FEATURES: recent results proven the scaffolds to guide neural hMSC lineage differentiation without specific differentiation media or stimulus. Results are published in RCS Interface Focus!
NEW FEATURES: the scaffolds proven to modulate specific gene switching in four different cancer cell types (breast cancer, osteosarcoma, neuroblastoma, melanoma) with intrinsic auto-mechanotransduction and to alter gene expression in response to chemotherapy. Results are published in ACS Biomaterials Science and Engineering (now with Open Access!)
WORK IN PROGRESS: the scaffolds have initially demonstrate specific reactions with some viruses. The work is being carried out and the results will be reported as will be ready. Stay tuned!